EDRF generation and release from perfused bovine pulmonary artery and vein

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

Robert F. Furchgott, John V. Zawadzki · Nature · 1980 · 12K citations

Life Sciences, Cell Biology, Physiology +15

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

Ryszard J. Gryglewski, Richard Palmer, Salvador Moncada · Nature · 1986 · 2.4K citations

Life Sciences, Cell Biology, Physiology +13

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

L J Ignarro, Howard Lippton, Jo C. W. Edwards et al. · Journal of Pharmacology and Experimental Therapeutics · 1981 · 1.6K citations

Life Sciences, Biophysics, Physiology +6

Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

William Martin, G. Villani, D Jothianandan et al. · Journal of Pharmacology and Experimental Therapeutics · 1985 · 1.3K citations

Medicine, Pharmacology, Physiology +8

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

Gabor M. Rubanyi, Paul M. Vanhoutte · American Journal of Physiology-Heart and Circulatory Physiology · 1986 · 1.2K citations · Full text

Life Sciences, Cardiology, Pharmacology +15