HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

Jalview Version 2—a multiple sequence alignment editor and analysis workbench

Andrew Waterhouse, James B Procter, David Martin et al. · Bioinformatics · 2009 · 10.5K citations · Full text

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

Nadine Laguette, Bijan Sobhian, Nicoletta Casartelli et al. · Nature · 2011 · 1.5K citations

Human Retrovirus, Immunology, Antiviral Response +6

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Kasia Hrecka, Caili Hao, Magda Gierszewska et al. · Nature · 2011 · 1.2K citations

Inflammation, Medicine, Human Retrovirus +10

Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

Xianghui Yu, Yunkai Yu, Bindong Liu et al. · Science · 2003 · 1.2K citations

Molecular Virology, Vif Mutant, Human Retrovirus +14

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

David C. Goldstone, Valerie Ennis-Adeniran, Joseph J. Hedden et al. · Nature · 2011 · 803 citations · Full text

Human Retrovirus, Immunology, Antiviral Response +5