Concepedia

Down-Regulation of ECRG4, a Candidate Tumor Suppressor Gene, in Human Breast Cancer

Renaud Sabatier, Pascal Finetti, José Adélaı̈de, Arnaud Guillé, Jean‐Paul Borg, Max Chaffanet, Lydie Lane, Daniel Birnbaum, François Bertucci

PLoS ONE · 2011 · 159 citations · 27 references

DOIFull text

Open access

Abstract

Our data suggest that ECRG4 is a candidate TSG in breast cancer, the expression of which may help improve the prognostication. If functional analyses confirm this TSG role, restoring ECRG4 expression in the tumor may represent a promising therapeutic approach.

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