Concepedia

Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats*

Parisa Partownavid, Soban Umar, Jingyuan Li, Siamak Rahman, Mansoureh Eghbali

Critical Care Medicine · 2012 · 110 citations · 32 references

DOIFull text

Open access

Abstract

Fatty-acid oxidation is required for successful rescue of bupivacaine-induced cardiotoxicity by lipid emulsion. This rescue action is associated with inhibition of mitochondrial permeability transition pore opening.

References

32

The mitochondrial permeability transition pore and its role in cell death

Martin Crompton · Biochemical Journal · 1999 · 2.3K citations · Full text

Pretreatment or Resuscitation with a Lipid Infusion Shifts the Dose-Response to Bupivacaine-induced Asystole in Rats 

Guy Weinberg, Timothy R. VadeBoncouer, Gopal A. Ramaraju et al. · Anesthesiology · 1998 · 662 citations · Full text

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

Andrew P. Halestrap, Paul M. Kerr, Sabzali Javadov et al. · Biochimica et Biophysica Acta (BBA) - Bioenergetics · 1998 · 483 citations

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Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity

Guy Weinberg · Regional Anesthesia & Pain Medicine · 2003 · 439 citations

Lipid Emulsion Infusion Rescues Dogs From Bupivacaine-Induced Cardiac Toxicity

Guy Weinberg, Richard Ripper, Douglas L. Feinstein et al. · Regional Anesthesia & Pain Medicine · 2003 · 370 citations

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