Phosphorylation of Extracellular Signal-Regulated Kinase in medullary and upper cervical cord neurons following noxious tooth pulp stimulation

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Michael J. Caterina, Mark Schumacher, Makoto Tominaga et al. · Nature · 1997 · 9K citations · Full text

Acute Pain, Pain Medicine, Anesthetic Mechanism +16

Ethical guidelines for investigations of experimental pain in conscious animals

M. Zimmermann · Pain · 1983 · 7.7K citations

Pain Therapy, Pain Syndrome, Behavioral Sciences +12

Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

Ru‐Rong Ji, Hiroshi Baba, Gary J. Brenner et al. · Nature Neuroscience · 1999 · 779 citations

Pain Syndrome, Health Sciences, Neurophysiology +13

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

Zhi‐Ye Zhuang, Peter Gerner, Clifford J. Woolf et al. · Pain · 2005 · 766 citations

Pain Medicine, Erk Kinase, Neuropathic Pain +18

ERK MAP Kinase Activation in Superficial Spinal Cord Neurons Induces Prodynorphin and NK-1 Upregulation and Contributes to Persistent Inflammatory Pain Hypersensitivity

Ru‐Rong Ji, Katia Befort, Gary J. Brenner et al. · Journal of Neuroscience · 2002 · 451 citations · Full text

Pain Medicine, Immunology, Neuropathic Pain +17