Transcriptional Repressor NIR Functions in the Ribosome RNA Processing of Both 40S and 60S Subunits

Abstract

We provide the first evidence for a transcriptional repressor to function in the rRNA biogenesis of both the 40S and 60S subunits. Our findings also suggested that a nucleolar protein may alternatively signal to p53 by affecting the p53 modification rather than affecting p53 protein level.