Cross hepatotoxicity between non-steroidal anti-inflammatory drugs.

Abstract

Non-steroidal atiti-infiimmatory drugs such as ibuprofen, flurbiprofen, ketoprofen, naproxen, and fenoprofen are generally considered to be well tolerated and effective. Benoxaprofen, which is structurally related to these drugs, was withdrawn from use because. of severe and potentially lethal hepatotoxicity and other side effects. Less severe and apparently less frequent hepatic impairment has been reported with ibuprofen, naproxen, and fenoprofen.' We report a case of cross hepatotoxicity between two derivatives of propionic acid, naproxen and fenoprofen.