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4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARα/γ agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations

Cécile Parmenon, Jérôme Guillard, Daniel‐Henri Caignard, Nathalie Hennuyer, Bart Staels, Valérie Audinot‐Bouchez, Jean A. Boutin, Catherine Dacquet, Alain Ktorza, Marie‐Claude Viaud‐Massuard

Bioorganic & Medicinal Chemistry Letters · 2009 · 18 citations · 14 references

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14

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Jürgen M. Lehmann, Linda B. Moore, Tracey Smith-Oliver et al. · Journal of Biological Chemistry · 1995 · 3.6K citations · Full text

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Isabelle Issemann, Stephen Green · Nature · 1990 · 3.5K citations

, , +9

Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells

Show‐Ling Shyng, Sylvain Lehmann, Krista L. Moulder et al. · Journal of Biological Chemistry · 1995 · 703 citations · Full text

The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

Timothy M. Willson, Jeffery E. Cobb, David J. Cowan et al. · Journal of Medicinal Chemistry · 1996 · 637 citations · Full text

, , +18

<i>N</i>-(2-Benzoylphenyl)-<scp>l</scp>-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents

Brad R. Henke, Steven G. Blanchard, Marcus F. Brackeen et al. · Journal of Medicinal Chemistry · 1998 · 299 citations · Full text

, , +17