Concepedia

The PDE1A-PKCα Signaling Pathway Is Involved in the Upregulation of α-Smooth Muscle Actin by TGF-β<sub>1</sub> in Adventitial Fibroblasts

Haiyan Zhou, Wen-Dong Chen, Dingliang Zhu, Lingyun Wu, Jia Zhang, Weiqing Han, Jiandong Li, Yan Chen, Pingjin Gao

Journal of Vascular Research · 2009 · 25 citations · 21 references

DOIFull text

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Abstract

Taken together, our data suggest that TGFbeta(1) induces alpha-SMA expression and myofibroblast formation via a PDE1A-PKCalpha-dependent mechanism. Our study thus unveils a novel signaling mechanism underlying TGF-beta(1)-induced adventitial myofibroblast formation.

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