Concepedia

The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal

Paiboon Jungsuwadee, Tianyong Zhao, Elzbieta I. Stolarczyk, Christian M. Paumi, D. Allan Butterfield, Daret K. St. Clair, Mary Vore

Pharmacogenetics and Genomics · 2012 · 33 citations · 27 references

DOIFull text

Open access

Abstract

These data suggest that decreased MRP1-dependent GS-HNE efflux contributes to increased doxorubicin toxicity in HEKG671V and potentially in individuals carrying the G671V variant.

References

27

NAD(P)H Oxidase and Multidrug Resistance Protein Genetic Polymorphisms Are Associated With Doxorubicin-Induced Cardiotoxicity

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Ina Hubatsch, Marianne Ridderström, Bengt Mannervik · Biochemical Journal · 1998 · 374 citations · Full text

Determining Glutathione and Glutathione Disulfide Using the Fluorescence Probe o-Phthalaldehyde

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, , +11