The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Alexandra E. Butler, Juliette Janson, Susan Bonner‐Weir et al. · Diabetes · 2003 · 4K citations

Medicine, Endocrinology, Physiology +17

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

Catherine Postic, Masakazu Shiota, Kevin D. Niswender et al. · Journal of Biological Chemistry · 1999 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Seth L. Masters, Aisling Dunne, Shoba Subramanian et al. · Nature Immunology · 2010 · 1.3K citations · Full text

Life Sciences, Endocrinology, Immunology +14

Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

Angelo Demuro, Erene Mina, Rakez Kayed et al. · Journal of Biological Chemistry · 2005 · 1K citations · Full text

Life Sciences, Biochemistry, Neuroscience +16

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Kathrin Maedler, Frédéric Ris, José Oberholzer et al. · Journal of Clinical Investigation · 2002 · 992 citations · Full text

Life Sciences, Cell Biology, Endocrinology +17