Concepedia

Role of 5‐HT<sub>2A</sub>, 5‐HT<sub>4</sub>and 5‐HT<sub>7</sub>receptors in the antigen‐induced airway hyperresponsiveness in guinea‐pigs

Mario H. Vargas, Guadalupe Córdoba-Rodríguez, Jaime Chávez, José Luis Arreola, Patricia Campos‐Bedolla, Vı́ctor Ruiz, Luz María García-Hernández, Cármen Méndez, Luis M. Montaño

Clinical & Experimental Allergy · 2009 · 23 citations · 49 references

DOI

Abstract

Our results suggested that 5-HT was involved in the development of AI-AHR to ACh in guinea-pigs. Specifically, 5-HT(2A), 5-HT(4) and 5-HT(7) receptors seem to be particularly involved in this phenomenon. Participation of 5-HT might probably be favoured by the enhancement of the PNECs 5-HT content observed after sensitization.

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