Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science · 1993 · 9.5K citations

Life Sciences, Genetics, Neurology +17

Real time quantitative PCR.

Chris Heid, Junko Stevens, Kenneth J. Livak et al. · Genome Research · 1996 · 6.2K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +13

Detection of specific polymerase chain reaction product by utilizing the 5'----3' exonuclease activity of Thermus aquaticus DNA polymerase.

Pamela M. Holland, Richard D. Abramson, R. R. Watson et al. · Proceedings of the National Academy of Sciences · 1991 · 2.7K citations

Life Sciences, Biotechnology, Molecular Biology +15

Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

Robert F. Mullins, Stephen R. Russell, Don H. Anderson et al. · The FASEB Journal · 2000 · 936 citations · Full text

Medicine, Ophthalmology, Pathology +17

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

J K Boyles, Robert E. Pitas, Elaine V. Wilson et al. · Journal of Clinical Investigation · 1985 · 829 citations · Full text

Medicine, Neurobiology, Neuroscience +11