Concepedia

Local free light chain expression is increased in chronic rhinosinusitis with nasal polyps

Tom Groot Kormelink, Lien Calus, Natalie De Ruyck, Gabriële Holtappels, Claus Bachert, F.A.M. Redegeld, Philippe Gevaert

Allergy · 2012 · 23 citations · 32 references

DOI

Abstract

The presence of FLC in CRSwNP and CRSsNP suggests a possible role in mediating the local immune reaction in the paranasal cavities. Furthermore, the decrease in local FLCs after treatment with anti-IL-5 presumes that IL-5 creates an environment that favors FLC production.

References

32

EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists

W. J. Fokkens, Valerie J. Lund, J Mullol et al. · Rhinology Journal · 2012 · 2.4K citations

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EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists

Wytske J. Fokkens, Valerie Lund, Joaquim Mullol et al. · Rhinology Journal · 2012 · 1.2K citations · Full text

Differentiation of chronic sinus diseases by measurement of inflammatory mediators

Thibaut Van Zele, Sofie Claeys, Philippe Gevaert et al. · Allergy · 2006 · 770 citations

Total and specific IgE in nasal polyps is related to local eosinophilic inflammation

Claus Bachert, Philippe Gevaert, Gabriële Holtappels et al. · Journal of Allergy and Clinical Immunology · 2001 · 690 citations

, , +9

Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains.

Jerry A. Katzmann, Raynell Clark, Roshini S. Abraham et al. · PubMed · 2002 · 620 citations