Annals of the New York Academy of Sciences · 1992 · 19 citations · 6 references
Primary InflammationPain MedicineImmunologyAntioxidant ActivityMolecular PainAdjuvant‐induced DiseasePharmacotherapyOxidative StressInflammationPain ManagementAnalgesicsHealth SciencesSecondary LesionsChronic InflammationPharmacological AgentNeuropharmacologyPharmacologyPain ResearchAnti-inflammatoryMedicineOpioid Use DisorderAnesthesiology
A centrally acting analgesic-opioid agonist, PM, suppresses the primary inflammation and the secondary lesions of adjuvant-induced disease in rats. This compound also possesses antioxidant properties and inhibits the carrageenin-induced edema in mice. PM, therefore, is interfering to immune functions probably by binding to opioid receptors on lymphocytes and to inflammatory cells by its antioxidant activity.
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