Concepedia

Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1.

John M. Maris, Susan R. Wiersma, Nahla Mahgoub, Patricia Thompson, Russell Geyer, Craig G. Hurwitz, Beverly J. Lange, Kevin Shannon

PubMed · 1997 · 89 citations · 41 references

Abstract

Children with NF1 are susceptible to the development of malignant myeloid disorders both as a primary event and as an SMN. Additional molecular genetic analysis is necessary to determine if the NF1 gene is inactivated by somatic mutation in these secondary leukemias.

References

41

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

Margaret R. Wallace, Douglas A. Marchuk, Lone B. Andersen et al. · Science · 1990 · 1.5K citations

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Neurofibromatosis. Conference statement, National Institute of Health development conference

Da Stumpf · JAMA Neurology · 1988 · 1.2K citations

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The neurofibromatosis type 1 gene encodes a protein related to GAP

Gangfeng Xu, P. O’Connell, David Viskochil et al. · Cell · 1990 · 1.1K citations

, , +6

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

Richard Cawthon, Robert B. Weiss, Gangfeng Xu et al. · Cell · 1990 · 1.1K citations

, , +9

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus

David Viskochil, Arthur M. Buchberg, Gangfeng Xu et al. · Cell · 1990 · 1.1K citations

, , +9