Pharmacokinetics of halogenated ethylenes in rats

Resolution of dose-response toxicity data for chemicals requiring metabolic activation: Example?Vinyl chloride*1

P.J. Gehring · Toxicology and Applied Pharmacology · 1978 · 154 citations

Predictive Toxicology, Biochemistry, Metabolic Activation +15

Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation

Gerhard Bonse, T Urban, D. Reichert et al. · Biochemical Pharmacology · 1975 · 128 citations

Biological Reactivity, Liver Physiology, Metabolic Oxirane Formation +8

Disposition of [1,2-14C] vinyl chloride in the rat

Hermann M. Bolt, H. Kappus, Axel Buchter et al. · Archives of Toxicology · 1976 · 92 citations

Medicine, Physiology, Toxicology +5

Liver microsomal uptake of 614C9vinyl chloride and transformation to protein alkylating metabolites in vitro

H. Kappus · Toxicology and Applied Pharmacology · 1976 · 71 citations

Liver, Hepatology, Biochemistry +13

Metabolism and pharmacokinetic profile of vinylidene chloride in rats following oral administration

Michael J. McKenna, J.A. Zempel, E.O. Madrid et al. · Toxicology and Applied Pharmacology · 1978 · 59 citations

Pharmacological Study, Pharmacokinetic Profile, Physiologically-based Pharmacokinetic Modeling +10