Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

Ann M. Sheehy, Nathan Gaddis, Jonathan Choi, +1

Nature

Molecular VirologyHuman RetrovirusPathogenesisImmunologyAntiviral Response +10

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

Bastien Mangeat, Priscilla Turelli, Gersende Caron, +3

Nature

MedicineHuman RetrovirusImmunologyAntiviral ResponseAntiviral Drug Development +7

DNA Deamination Mediates Innate Immunity to Retroviral Infection

Reuben S. Harris, Kate N. Bishop, Ann M. Sheehy, +5

Cell

Retroviral InfectionViral PersistenceHuman RetrovirusImmunologyVirology +2

Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

Xianghui Yu, Yunkai Yu, Bindong Liu, +4

Science

Molecular VirologyVif MutantHuman RetrovirusViral ImmunityImmunology +12

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

Hui Zhang, Bin Yang, Roger J. Pomerantz, +3

Nature

Viral ReplicationBiochemistryNatural SciencesHuman RetrovirusHiv-1 Dna +5

The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

Ann M. Sheehy, Nathan Gaddis, Michael H. Malim

Nature Medicine

Antiretroviral Enzyme Apobec3gProtein FoldingMedicineNatural SciencesImmunology +10

Species-Specific Exclusion of APOBEC3G from HIV-1 Virions by Vif

Roberto Mariani, Darlene Chen, Bärbel Schröfelbauer, +6

Cell

Molecular VirologyHuman RetrovirusPathogenesisImmunologyVirology +5

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Svend K. Petersen‐Mahrt, Reuben S. Harris, Michael S. Neuberger

Nature

E. ColiAntibody DiversificationGeneticsDirected EvolutionMolecular Biology +8

HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation

Mariana Marin, Kristine M. Rose, Susan L. Kozak, +1

Nature Medicine

Viral ReplicationHuman RetrovirusImmunologyAntiviral ResponseMolecular Biology +5

HIV-1 Vif Blocks the Antiviral Activity of APOBEC3G by Impairing Both Its Translation and Intracellular Stability

Kim Stopak, Carlos de Noronha, Wes Yonemoto, +1

Molecular Cell

Hiv-1 Vif BlocksAntiviral ActivityHuman RetrovirusImmunologyAntiviral Response +10