Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices

Mucus clearance as a primary innate defense mechanism for mammalian airways

Michael R. Knowles, Richard C. Boucher · Journal of Clinical Investigation · 2002 · 1K citations

Asthma, Innate Immune System, Immunology +17

Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials

Peter M.A. Calverley, Klaus F. Rabe, Udo-Michael Goehring et al. · The Lancet · 2009 · 808 citations · Full text

Antifibrotic Therapy, Pulmonary Care, Clinical Trials +3

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

Leonardo M. Fabbri, Peter M.A. Calverley, José Luís Izquierdo Alonso et al. · The Lancet · 2009 · 604 citations · Full text

Longacting Bronchodilators, Advanced Lung Disease, Clinical Trials +4

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

Kimberly L. Dodge · The EMBO Journal · 2001 · 500 citations · Full text

Protein Function, Molecular Physiology, Signal Transduction +10

Roflumilast—an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial

Klaus F. Rabe, Eric Bateman, Denis O’Donnell et al. · The Lancet · 2005 · 466 citations

Asthma, Inflammation, Antifibrotic Therapy +6