TC21/R-Ras2 Upregulation in Esophageal Tumorigenesis: Potential Diagnostic Implications

Abstract

To our knowledge, this is the first report demonstrating differential expression of TC21 in normal, dysplastic and ESCC tissues, suggesting that TC21 expression is associated with early stages of esophageal tumorigenesis. Nuclear localization of TC21 makes it the third of over 100 small SMGs identified to be localized in the nucleus.