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Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors

Makoto Shiozaki, Hiroto Imai, Katsuya Maeda, Tomoya Miura, Katsutaka Yasue, Akira Suma, Masahiro Yokota, Yosuke Ogoshi, Julia Haas, Andrew M. Fryer,

Bioorganic & Medicinal Chemistry Letters · 2009 · 19 citations · 19 references

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Dimethyloxosulfonium Methylide ((CH<sub>3</sub>)<sub>2</sub>SOCH<sub>2</sub>) and Dimethylsulfonium Methylide ((CH<sub>3</sub>)<sub>2</sub>SCH<sub>2</sub>). Formation and Application to Organic Synthesis

E. J. Corey, Michael Chaykovsky · Journal of the American Chemical Society · 1965 · 1.6K citations

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

S.S. Glasson, Roger Askew, Barbara Sheppard et al. · Nature · 2005 · 1.3K citations

, , +14

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Heather Stanton, Fraser M. Rogerson, Charlotte J. East et al. · Nature · 2005 · 915 citations

, , +14

Ligand efficiency indices as guideposts for drug discovery

C ABADZAPATERO · Drug Discovery Today · 2005 · 523 citations

, , +14

Mild Conditions for Copper‐Catalysed <i>N</i>‐Arylation of Pyrazoles

Henri‐Jean Cristau, Pascal P. Cellier, Jean‐Francis Spindler et al. · European Journal of Organic Chemistry · 2004 · 287 citations

, , +17