Concepedia

Negative Effects of Progesterone Receptor Isoform-A on Human Placental Activity of the Noncanonical NF-κB Signaling

Bingbing Wang, Nataliya Parobchak, Max Rosen, Natalie Roche, Todd Rosen

The Journal of Clinical Endocrinology & Metabolism · 2013 · 21 citations · 29 references

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Abstract

P4 inhibits the pro-labor genes CRH and COX-2 via PR-A repression of the noncanonical NF-κB signaling in human placenta. Characterization of these pathways may identify potential drug targets for prevention of preterm birth.

References

29

Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone Caproate

Paul J. Meis, Mark A. Klebanoff, Elizabeth Thom et al. · New England Journal of Medicine · 2003 · 1.6K citations · Full text

Progesterone and the Risk of Preterm Birth among Women with a Short Cervix

Eduardo Borges da Fonseca, Ebru Çelik, M. Parra et al. · New England Journal of Medicine · 2007 · 1.1K citations

A placental clock controlling the length of human pregnancy

Mark McLean, Andrew Bisits, Joanne Davies et al. · Nature Medicine · 1995 · 915 citations

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The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

Emmanuel Dejardin, Nathalie Droin, Mireille Delhase et al. · Immunity · 2002 · 910 citations · Full text

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Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double‐blind, placebo‐controlled trial

Sonia S. Hassan, Roberto Romero, D. Vidyadhari et al. · Ultrasound in Obstetrics and Gynecology · 2011 · 909 citations · Full text