Concepedia

Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG)

Cardiovascular Research · 2003 · 77 citations · 37 references

Open access

Abstract

The K897T variation has an effect on channel function and clinical phenotype. Our data warrant further investigations into the significance of this polymorphism in drug-induced and inherited LQTS.

References

37

World Medical Association Declaration of Helsinki

JAMA · 2013 · 27.3K citations

Biomedical Ethic, Ethical Principles, Research Ethics +19

An analysis of the time-relations of electrocardiograms

H. C. Bazett · 1920 · 3.8K citations

Electrophysiological Evaluation, Measurement, Biosignal Processing +6

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

Mark Curran, Igor Splawski, Katherine W. Timothy et al. · Cell · 1995 · 2.3K citations · Full text

Long Qt Syndrome, Cardiomyopathy, Genetics +9

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Q. Wang, Mark Curran, Igor Splawski et al. · Nature Genetics · 1996 · 1.8K citations

Cardiac Muscle, Channelopathies, Kvlqt1 Mutations +9

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

Qing Wang, Jiaxiang Shen, Igor Splawski et al. · Cell · 1995 · 1.7K citations · Full text

Long Qt Syndrome, Cardiomyopathy, Genetic Disorder +6