Effect of Clenbuterol on Contractile Response in Periurethral Striated Muscle of Rabbits.

Abstract

KISHIMOTO, T., MORITA, T., OKAMIYA, Y., HOSHINA, K. and TAKESHITA, T. Effect of Clenbuterol on Contractile Response in Periurethral Striated Muscle of Rabbits. Tohoku J. Exp. Med., 1991, 165 (3), 243-245-The effect of Clenbuterol, a selective β2-adrenoceptor agonist, on isolated periurethral striated muscle preparations from rabbits has been investigated. The periurethral striated muscle produced a contraction in response to field stimulation. An application of Clenbuterol resulted in a dose-dependent potentiation of the field stimulation-induced contraction. This potentiation was antagonized by propranolol and was greater than that of isoproterenol, suggesting a β2-agonistic action.