RESULTS OF IMMUNIZATION BY MEANS OF ACTIVE VIRUS OF HUMAN INFLUENZA 1

Abstract

The studies reported here deal with the pre-vention of " influenza " in a group of individuals immunized by means of intramuscular injections of active 2 human influenza virus in the presence of an oncoming epidemic which occasioned a marked morbidity in the unvaccinated people of the same community. Shope (1, 2, 3, 4) first reported the successful immunization of hogs against swine influenza by the intramuscular injection of active swine influ-enza virus; the swine were immunized not only against the mild respiratory disease, " filtrate dis-ease, " caused by the virus alone, but also against the severe respiratory disease, true swine influ-enza, which is caused by the synergistic activity of the swine influenza virus and Hemophilus in-fluenzae suis, an organism indistinguishable morphologically and culturally from the non-indol-producing strains of the human Pfeiffer's bacillus. Smith,. Andrewes, and Laidlaw (5, 6,