Concepedia

TRPP2 and TRPV4 Form an EGF-Activated Calcium Permeable Channel at the Apical Membrane of Renal Collecting Duct Cells

Zhi‐Ren Zhang, Wenfeng Chu, Bin‐Lin Song, Mónika Göőz, Jianing Zhang, Changjiang Yu, Shuai Jiang, Aleksander Baldys, Pal Göőz, Stacy L. Steele,

PLoS ONE · 2013 · 55 citations · 29 references

DOIFull text

Open access

Abstract

We conclude that in the absence of cilia, an EGF activated TRPP2\TRPV4 channel may play an important role in increased cell proliferation and cystogenesis.

References

29

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Catherine D. Van Raamsdonk, Vladimir Bezrookove, Gary Green et al. · Nature · 2008 · 1.6K citations · Full text

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<b> <i>PKD2</i> </b> , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein

Toshio Mochizuki, Guanqing Wu, Tomohito Hayashi et al. · Science · 1996 · 1.4K citations

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

Hiroyuki Watanabe, Joris Vriens, Jean Prenen et al. · Nature · 2003 · 1K citations

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Use of Manganese to Discriminate Between Calcium Influx and Mobilization From Internal Stores in Stimulated Human Neutrophils

J E Merritt, Ron Jacob, T J Hallam · Journal of Biological Chemistry · 1989 · 519 citations · Full text

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca <sup>2+</sup> -permeable nonselective cation channel

Silvia González‐Perrett, Kee‐Tae Kim, Cristina Ibarra et al. · Proceedings of the National Academy of Sciences · 2000 · 444 citations · Full text

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