Identification and in vivo efficacy of small-molecule antagonists of integrin αvβ3 (the vitronectin receptor)

Principles of Bone Biology

Juliet Compston · Clinical Endocrinology · 1997 · 1.4K citations

Medicine, Anatomy, Orthopaedic Surgery +12

Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins.

Martin Pfaff, Kirsten Tangemann, Beate Müller et al. · Journal of Biological Chemistry · 1994 · 534 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist

Chris Storgard, Dwayne G. Stupack, Alfred Jonczyk et al. · Journal of Clinical Investigation · 1999 · 310 citations · Full text

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A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo.

V. Wayne Engleman, G. Allen Nickols, F. Patrick Ross et al. · Journal of Clinical Investigation · 1997 · 287 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Role of αvβ3 integrin in osteoclast migration and formation of the sealing zone

Ichiro Nakamura, Mary F. Pilkington, Päivi T. Lakkakorpi et al. · Journal of Cell Science · 1999 · 197 citations

Medicine, Cell Biology, Cell Adhesion +14