MMP‐2, TIMP‐1, E‐cadherin, and β‐catenin expression in endometrial serous carcinoma compared with low‐grade endometrial endometrioid carcinoma and proliferative endometrium

Abstract

We suggest that MMP-2 and TIMP-1 expression and loss of beta-catenin have a role in the pathogenesis and progression of ESC. Decreased E-cadherin may have an important role in the development of both ESC and EEC. Furthermore, the dissimilarities in MMP-2, TIMP-1, E-cadherin and beta-catenin expressions in ESC compared with EEC may be responsible, along with other factors, for their different biological behavior.