Doxorubicin-Loaded PLGA Nanoparticles by Nanoprecipitation: Preparation, Characterization and <i>In Vitro</i> Evaluation

Abstract

Nanoparticles formulated by nanoprecipitation of acid-ended poly(lactic-co-glycolic acid) were found to be able to control the release of doxorubicin in a pH-dependent manner and to effectively deliver high payloads of the drug in an active form to MDA-MB-231 breast cancer cells.