Stem Cells · 2008 · 179 citations · 39 references
MedicineCell BiologyImmunologyBone MetabolismCellular PathologyStem Cell BiologyBone DevelopmentBone FormationBone HealingBone PathologyOsteogenesisSkeletal DevelopmentBone BiologyOral Soft Tissue InjuriesProgenitor Cells
Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within extraskeletal soft tissues, is a serious bony disorder that may be either acquired or hereditary. We utilized an animal model of the genetic disorder fibrodysplasia ossificans progressiva to examine the cellular mechanisms underlying HO. We found that HO in these animals was triggered by soft tissue injuries and that the effects were mediated by macrophages. Spreading of HO beyond the initial injury site was mediated by an abnormal adaptive immune system. These observations suggest that dysregulation of local stem/progenitor cells could be a common cellular mechanism for typical HO irrespective of the signal initiating the bone formation.
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RAG-1-deficient mice have no mature B and T lymphocytes
Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations
Life Sciences, Genetics, Immunology +13
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Björn E. Clausen, Christoph Burkhardt, Walter Reith et al. · Transgenic Research · 1999 · 2.2K citations