Concepedia

Passive Immunization with Hypochlorite-oxLDL Specific Antibodies Reduces Plaque Volume in LDL Receptor-Deficient Mice

Marcella van Leeuwen, Michael J. Kemna, Menno P.J. de Winther, Louis Boon, Adriaan Duijvestijn, Darius Henatsch, Nicolaas A. Bos, Marion J. Gijbels, Jan Willem Cohen Tervaert

PLoS ONE · 2013 · 15 citations · 34 references

DOIFull text

Open access

Abstract

Our data show that passive immunization with a natural IgM antibody, directed to HOCl-oxLDL, can reduce atherosclerotic plaque development. We postulate that specific antibody therapy may be developed for use in human cardiovascular diseases.

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