Concepedia

Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus

Robert J. Kerns, Michael J. Rybak, Glenn W. Kaatz, Flamur Vaka, Raymond Cha, Richard G. Grucz, Veena U. Diwadkar, Tracey D. Ward

Bioorganic & Medicinal Chemistry Letters · 2003 · 54 citations · 9 references

DOI

Concepts

References

9

DNA gyrase, topoisomerase IV, and the 4-quinolones.

Karl Drlica, Xilin Zhao · Microbiology and Molecular Biology Reviews · 1997 · 891 citations

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Crystal structure of the breakage–reunion domain of DNA gyrase

João H. Morais‐Cabral, Andrew P. Jackson, Clare V. Smith et al. · Nature · 1997 · 456 citations

, , +8

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model

Linus L. Shen, Lester A. Mitscher, Padam N. Sharma et al. · Biochemistry · 1989 · 416 citations

, , +16

Inducible NorA-mediated multidrug resistance in Staphylococcus aureus

Glenn W. Kaatz, S M Seo · Antimicrobial Agents and Chemotherapy · 1995 · 262 citations

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Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus

E Y Ng, Michele Trucksis, David C. Hooper · Antimicrobial Agents and Chemotherapy · 1996 · 232 citations · Full text

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