Antifungal activity of 5flurocytosine as measured by disc diffusion susceptibility testing,

Abstract

Premna serratifolia Lin., belonging to the family Verbenaceae was screened to evaluate in vitro antimicrobial activity against the selected human pathogenic organisms. In the present investigation, different extracts (n-hexane, chloroform, ethylacetate, ethanol and ethanol fractions (No. I to VII) of the roots of the plant were obtained. Preliminary phytochemical reports of the extracts and fractions showed the presence of phytoconstituents like flavonoids, steroids, alkaloids, glycosides and phenolic compounds. Findings showed potential antimicrobial properties of the extracts (133.33mg/ml) and fractions (33.33mg/ml) of root of Premna serratifolia Lin., against the different bacterial organisms and fungal tested and the zone of inhibition of the extracts and fraction were comparable with that of standard antibiotics. The study suggests that the plant is promising for development of phytomedicine for antimicrobial properties and also indicates the potential usefulness of Premna serratifolia Lin., in the treatment of various pathogenic disease which in future can be developed as a potential antimicrobial agent with reduced toxicity and adverse effects when compared with the synthetic chemotherapeutic agents.