Concepedia

Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine

Fayaz Malik, Ajay Kumar, Shashi Bhushan, Sheema Khan, Aruna Bhatia, Krishan Avtar Suri, Ghulam N. Qazi, Jaswant Singh

APOPTOSIS · 2007 · 252 citations · 33 references

Concepts

N-acetyl CysteineMitochondrial FunctionBiochemistryMitochondrial DysfunctionMedicineApoptosisLipid PeroxidationCell DeathReactive Oxygen SpecieDietary CompoundMetabolismPharmacologyCell BiologyRedox BiologyOxidative Stress

References

33

A fluorometric method for determination of oxidized and reduced glutathione in tissues

Paul J. Hissin, Russell Hilf · Analytical Biochemistry · 1976 · 4.1K citations

Fluorometric Method, Biochemistry, Lipid Peroxidation +9

Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain

Julie St‐Pierre, Julie A. Buckingham, Stephen J. Roebuck et al. · Journal of Biological Chemistry · 2002 · 1.5K citations · Full text

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

Matthew G. Vander Heiden, Navdeep S. Chandel, Edward K. Williamson et al. · Cell · 1997 · 1.4K citations · Full text

Volume Homeostasis, Signal Transduction, Mitochondrial Function +9

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

Robert Eskes, Solange Desagher, Bruno Antonsson et al. · Molecular and Cellular Biology · 2000 · 1.2K citations · Full text

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

Deborah M. Finucane, Ella Bossy‐Wetzel, Nigel J. Waterhouse et al. · Journal of Biological Chemistry · 1999 · 723 citations · Full text