Gene-target recognition among members of the Myc superfamily and implications for oncogenesis

Improved methods for building protein models in electron density maps and the location of errors in these models

T. Alwyn Jones, Jin-yu Zou, Sandra W. Cowan et al. · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 12.6K citations

Map Interpretation, Structural Bioinformatics, Biomolecular Structure Prediction +16

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Steffan N. Ho, Henry D. Hunt, Robert M. Horton et al. · Gene · 1989 · 7.5K citations

Natural Sciences, Genetics, Directed Evolution +6

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5K citations · Full text

Developmental Biology, Oncogenic Agent, Cellular Senescence +6

Use of a cDNA microarray to analyse gene expression patterns in human cancer

Joseph L. DeRisi, Lolita Penland, Patrick O. Brown et al. · Nature Genetics · 1996 · 2K citations

Functional Genomics, Cdna Microarray, Cancer Genomics +10

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

Andrea Kauffmann-Zeh, Pablo Rodriguez‐Viciana, Eugen Ulrich et al. · Nature · 1997 · 1.2K citations

Signal Transduction, Signaling Pathway, Cell Regulation +9