Concepedia

Enhanced FHL2 and TGF-β1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas

Philipp Westphal, Cornelia Mauch, Alexandra Florin, Jacqueline Czerwitzki, Nina Olligschläger, Claudia Wodtke, Roland Schüle, Reinhard Büttner, Nicolaus Friedrichs

American Journal of Clinical Pathology · 2015 · 14 citations · 36 references

DOIFull text

Open access

Abstract

Enhanced FHL2 and TGF-β1 expression is correlated with poor survival in human malignant melanoma. Protumorigenic effects of autocrine TGF-β1 secretion might be exerted by induction of FHL2 expression in melanoma cells. Since melanomas treated with targeted therapies often do not show sufficient response rates, inhibition of FHL2 and/or TGF-β1 might be a promising therapeutic approach.

References

36

Final Version of 2009 AJCC Melanoma Staging and Classification

Charles M. Balch, Jeffrey E. Gershenwald, Seng-Jaw Soong et al. · Journal of Clinical Oncology · 2009 · 4.5K citations · Full text

Increasing Burden of Melanoma in the United States

Eleni Linos, Susan M. Swetter, Myles Cockburn et al. · Journal of Investigative Dermatology · 2009 · 772 citations · Full text

, , +7

Androgen Receptor Coactivators Lysine-Specific Histone Demethylase 1 and Four and a Half LIM Domain Protein 2 Predict Risk of Prostate Cancer Recurrence

Philip Kahl, Lucia Gullotti, Lukas C. Heukamp et al. · Cancer Research · 2006 · 463 citations

, , +20

B-RAF is a therapeutic target in melanoma

Maria Karasarides, Antonio Chiloeches, Robert Hayward et al. · Oncogene · 2004 · 432 citations

, , +5

FHL2, a novel tissue-specific coactivator of the androgen receptor

Müller Jm · The EMBO Journal · 2000 · 327 citations · Full text

, , +5