A Convenient Method for Synthesis of Benzo[d]thiazoles in Water and Solvent Free Condition

Abstract

Benzo[d]thiazoles and their derivatives are of great interest during the last decades, because bicyclic aromatic rings containing benzo[d]thiazole derivatives have a wide range of biological properties1 and developed as new drugs for several diseases such as tumors, diabetes, Parkinson’s di-seases, tuberculosis, inflammatory diseases, epilepsy, viral infections, insomnia, and atherosclerosis.2 Due to the high profile of biological application of benzo[d]thiazole struc-tures, there are numerous methods have been reported for the synthesis of benzo[d]thiazoles. Benzo[d]thiazoles and their derivatives are most commonly synthesized by one of the following methods; the condensation of 2-aminothio-phenol with substituted carboxylic acids, aldehydes, acyl chlorides, and esters.3 And also many reactions for synthesis of benzo[d]thiazoles by cyclocondensation of 2-aminothio-phenol and aldehydes were proceeded under the presence of catalyst such as (pmlm)Br,4 I2,