FEBS Letters · 1993 · 134 citations · 23 references
MedicineMolecular BiologyPharmacologyCell SignalingMolecular PharmacologySignal TransductionG Protein-coupled Receptor SignalingLigand BindingReceptor BindingReceptor DesensitizationReceptor PharmacologyReceptor PhysiologyAdenylate Cyclase RegulationAdenylate Cyclase SignalingAdenylyl Cyclase RegulationG Protein-coupled Receptor BindingG Protein-coupled Receptor RegulationReceptor-g Protein CouplingSomatostatin PhysiologySomatostatin-mediated Inhibition
The somatostatin receptor 2 (mSSTR2) is alternatively spliced into two isoforms (mSSTR2A and mSSTR2B) which differ at the C-terminus. Both receptors bind somatostatin peptides with a similar high affinity when stably expressed in CHO-K1 cells. However, the spliced form (mSSTR2B) mediates a more efficient inhibition of adenylate cyclase and is much more resistant to agonist-induced reduction of binding than the longer form (mSSTR2A). These findings indicate that alternative splicing may be a physiological mechanism to modulate receptor desensitization and G-protein coupling of mSSTR2.
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Yuichiro Yamada, Steven R. Post, K Wang et al. · Proceedings of the National Academy of Sciences · 1992 · 765 citations · Full text
Cloning and expression of a novel mouse somatostatin receptor (SSTR2B)
Mirko Vanetti, Monika Kouba, Xiaomin Wang et al. · FEBS Letters · 1992 · 272 citations