Serotyping for Homotransplantation

Abstract

TWO recent developments have greatly changed the outlook of histocompatibility testing in clinical kidney transplantation. The first is the dramatic advances made in the area of serologic typing of leukocytes. The Third Histocompatibility Testing Workshop held in Torino, Italy, in June, 1967, showed that many laboratories are now identifying the same leukocyte antigens with considerable precision and that these antigens for the most part belong to a single complex system called HL-A.1 The second development has been the accumulation of evidence that these antigens function as histocompatibility antigens influencing kidney function, renal histology2 and survival of transplants3 from related donors. . . .