Nucleosides Nucleotides & Nucleic Acids · 2010 · 19 citations · 19 references
MedicineMolecular BiologyMolecular MedicineDiabetologyMolecular DiagnosticsMolecular PathologyDiabetes MellitusDiabetes Mellitus BiochemistryDiabetic RetinopathyRetinal Vascular DiseaseBiochemical Screening MarkersCirculating Cell-free Dna AnalysisDiabetic Retinopathy AssessmentDiabetic Retinopathy DetectionDiabetic Retinopathy ProgressionMicrovascular ComplicationsQuantitative Pcr DetectionType 2 Diabetes Mellitus Pathogenesis
In order to assess the potential biochemical markers in the development, diagnosis, and prognosis of diabetic patient with microvascular complication represented with retinopathy, we analyzed the levels of cell-free DNA by two different techniques. The levels of cell-free GAPDH assayed by quantitative PCR were significantly higher in the plasma samples of diabetic patients with and without diabetic retinopathy than in those of the control group; thus, it is a better biomarker than nucleosomes assayed by ELISA in patients with type 2 diabetes for the early detection of development of microvascular complications as retinopathy.
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Crystal structure of the nucleosome core particle at 2.8 Å resolution
Karolin Luger, Armin W. Mäder, Robin K. Richmond et al. · Nature · 1997 · 9.4K citations
Role of oxidative stress in development of complications in diabetes
J. W. Baynes · Diabetes · 1991 · 803 citations