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A New Dehydrogeranylgeraniol Antioxidant from <i>Saururus </i><i>c</i><i>ernuus</i> that Inhibits Intracellular Reactive Oxygen Species (ROS)-Catalyzed Oxidation within HL-60 Cells
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Citations
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2001
Year
Bioorganic ChemistryLipid PeroxidationSecondary MetaboliteOrganic ChemistryHl-60 CellsChemistryReactive Oxygen SpeciesRedox BiologyNew TrienePolyphenolicsOxidative StressToxicologyPhytochemicalCompound 1Redox SignalingBiochemistryNew Dehydrogeranylgeraniol AntioxidantReactive Oxygen SpeciePharmacologyNatural SciencesPhytochemistryMedicine
A new triene, 12,13-dehydrogeranylgeraniol (1), was isolated from the aquatic plant Saururus cernuus and its structure determined spectroscopically. Compound 1 inhibits PMA-induced peroxide-catalyzed oxidation of 2',7'-dichlorodihydrofluorescein dye (DCFH) by reactive oxygen species (ROS) within human promyelocyctic HL-60 cells.
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