Dynamic local unfolding in the serpin α-1 antitrypsin provides a mechanism for loop insertion and polymerization

Structure of a serpin–protease complex shows inhibition by deformation

James A. Huntington, Randy J. Read, Robin W. Carrell · Nature · 2000 · 1.1K citations

Protein Chemistry, Protein Assembly, Natural Sciences +2

Reexamination of the Folding of BPTI: Predominance of Native Intermediates

Jonathan S. Weissman, Peter S. Kim · Science · 1991 · 513 citations

Protein Chemistry, Native Intermediates, Protein Function +14

Inhibition of protein aggregation <i>in vitro</i> and <i>in vivo</i> by a natural osmoprotectant

Zoya Ignatova, Lila M. Gierasch · Proceedings of the National Academy of Sciences · 2006 · 316 citations · Full text

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

Masayuki Yamasaki, Wei Li, Daniel J. D. Johnson et al. · Nature · 2008 · 251 citations

Crystal Structure, Engineering, Self-assembly +9

Topography of a 2.0 Å structure of α₁‐antitrypsin reveals targets for rational drug design to prevent conformational disease

Peter R. Elliott, Xue Pei, Timothy R. Dafforn et al. · Protein Science · 2000 · 188 citations · Full text

Molecular Biology, Peptide Science, Analytical Ultracentrifugation +18