Immunosuppressive effects of soluble cell membrane fractions, donor blood and serum on renal allograft survival.

Abstract

Soluble cell membrane extracts of liver and spleen have been injected intravenously at the time of renal allografting. In dogs and rhesus monkeys there was slight prolongation of transplant survival in some experiments. Survival was markedly prolonged in 30 per cent of pigs, however. Donor blood and serum had a similar effect in protecting porcine liver allografts from rejection.