Chiral phosphine-phosphoramidite ligands for highly enantioselective hydrogenation of N-arylimines

Abstract

The asymmetric hydrogenation of<italic>N</italic>-arylimines with the chiral phosphine-phosphoramidite ligand, (<italic>Sc</italic>,<italic>Sa</italic>)-PEAPhos<bold>2b</bold>, has been developed, in which high turnover numbers and excellent enantioselectivity were achieved.