Concepedia

Development of small-molecule P-gp inhibitors of the N-benzyl 1,4-dihydropyridine type: Novel aspects in SAR and bioanalytical evaluation of multidrug resistance (MDR) reversal properties

Christiane Baumert, Marianne Günthel, Sören Krawczyk, Marc Hemmer, Tom Wersig, Andreas Langner, Joséf Molnár, Hermann Lage, Andreas Hilgeroth

Bioorganic & Medicinal Chemistry · 2012 · 34 citations · 18 references

DOI

Concepts

References

18

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

François‐Xavier Mahon, Françis Belloc, Valérie Lagarde et al. · Blood · 2003 · 538 citations · Full text

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Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

Marilyn M. Cornwell, Ira Pastan, Michael M. Gottesman · Journal of Biological Chemistry · 1987 · 535 citations · Full text

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ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.

Cheol-Hee Choi · Cancer Cell International · 2005 · 512 citations · Full text

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Structure–activity relationship of P-glycoprotein substrates and modifiers

Anna Seelig, Ewa Landwojtowicz · European Journal of Pharmaceutical Sciences · 2000 · 277 citations

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A Pharmacodynamic Study of Docetaxel in Combination with the P-glycoprotein Antagonist Tariquidar (XR9576) in Patients with Lung, Ovarian, and Cervical Cancer

Ronan J. Kelly, Deborah Draper, Clara C. Chen et al. · Clinical Cancer Research · 2010 · 172 citations · Full text

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