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A Defect in Cellular Immunity During the Incubation Period of Passage A Leukemia in G3H Mice.
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1965
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HistocompatibilitySkin GraftsIncubation PeriodLaboratory ImmunologyLymphocyte DevelopmentImmune RegulationImmunologyImmune SystemG3h MiceHematological MalignancyPassage A LeukemiaHematologyNeonatal Thymus ResultsSummarysix-week-old C3h MiceCell TransplantationAutoimmunitySelf-toleranceCell BiologyInborn Error Of ImmunityMedicine
SummarySix-week-old C3H mice injected neonatally with Gross passage A leukemia virus were found to be unable to reject skin grafts across a weak histocompatibility barrier. The similarity of the defects in the immune mechanisms of these mice to those of the neonatally thymectomized mice suggests that the establishment of the oncogenic agent in the neonatal thymus results in marked functional impairment long before histologic changes are apparent.