Concepedia

LRRK2 localizes to endosomes and interacts with clathrin‐light chains to limit Rac1 activation

Andrea M. A. Schreij, Mathilde Chaineau, Wenjing Ruan, Susan Yun-Fan Lin, Philip A. Barker, Edward A. Fon, Peter S. McPherson

EMBO Reports · 2014 · 60 citations · 33 references

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33

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Andrew B. West, Darren J. Moore, Saskia Biskup et al. · Proceedings of the National Academy of Sciences · 2005 · 1.2K citations · Full text

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Yuan Gao, J. Bradley Dickerson, Fukun Guo et al. · Proceedings of the National Academy of Sciences · 2004 · 1.1K citations · Full text

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

Wanli W. Smith, Zhong Pei, Haibing Jiang et al. · Nature Neuroscience · 2006 · 623 citations

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RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

David MacLeod, Hervé Rhinn, Tomoki Kuwahara et al. · Neuron · 2013 · 536 citations · Full text

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Endocytic Trafficking of Rac Is Required for the Spatial Restriction of Signaling in Cell Migration

Andrea Palamidessi, Emanuela Frittoli, Massimiliano Garrè et al. · Cell · 2008 · 437 citations · Full text

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