Epidemiology, pathophysiology, and initial management of chronic immune thrombocytopenic purpura

Abstract

The initial management of chronic ITP should consist of the use of oral corticosteroids according to national guidelines. In the absence of a response to this first-line therapy, intravenous gamma globulin, intravenous methylprednisolone, anti-D immunoglobulin, or splenectomy may be considered. These treatments may also be utilized to manage recurrent cases of ITP, prior to consideration of second-line therapies.