Concepedia

Single Nucleotide Polymorphisms of Toll-Like Receptor 4 Decrease the Risk of Development of Hepatocellular Carcinoma

Minmin Shi, Xu Xiaoqian, Hao Chen, Shen Baiyong, Xiaxing Deng, Xie Jun-jie, Zhan Xi, Zhao Jianquan, Songyao Jiang

PLoS ONE · 2011 · 76 citations · 28 references

DOIFull text

Open access

Abstract

Collectively, these results suggested that the risk of hepatocellular carcinoma was associated with TLR4 sequence variation. TLR4 single nucleotide polymorphisms may play an important protective role in the development of hepatocellular carcinoma.

References

28

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.5K citations

Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies

Sholom Wacholder, Stephen J. Chanock, Montserrat García‐Closas et al. · JNCI Journal of the National Cancer Institute · 2004 · 1.8K citations · Full text

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

Evelyn A. Kurt‐Jones, L. Popova, Laura Kwinn et al. · Nature Immunology · 2000 · 1.7K citations · Full text

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Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Yumiko Imai, Keiji Kuba, G. Gregory Neely et al. · Cell · 2008 · 1.3K citations · Full text

, , +10

Toll–Like Receptor 4 Is Involved in the Mechanism of Early Alcohol–Induced Liver Injury in Mice

Takehiko Uesugi, Matthias Froh, Gavin E. Arteel et al. · Hepatology · 2001 · 484 citations