Discovery of an orally bioavailable alkyl oxadiazole β3 adrenergic receptor agonist

A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys.

M. H. FISHER, A Amend, Tom Bach et al. · Journal of Clinical Investigation · 1998 · 115 citations · Full text

Metabolic Rate, Obesity, Molecular Pharmacology +17

Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block.

James G. Granneman, Kristine N. Lahners, Donald D. Rao · Molecular Pharmacology · 1992 · 93 citations

An improved oxadiazole synthesis using peptide coupling reagents

Gui‐Bai Liang, Dewei Feng · Tetrahedron Letters · 1996 · 72 citations

Biomolecular Engineering, Peptide Coupling Reagents, Peptide Synthesis

Potent, selective human β3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore

Robert J. Mathvink, Anna Maria Barritta, Mari R. Candelore et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 64 citations · Full text

Molecular Pharmacology, Substituted Indoline-5-sulfonamide Pharmacophore, Medicine +8

L-770,644: A potent and selective human β3 adrenergic receptor agonist with improved oral bioavailability

Thomas L. Shih, Mari R. Candelore, Margaret A. Cascieri et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 51 citations · Full text

Molecular Pharmacology, Improved Oral Bioavailability, Functional Selectivity +7